IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (N-Term) antibody

Details for Product No. ABIN183749
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Antigen
Synonyms 5830411O07Rik, Aiolos, Zfpn1a3, Znfn1a3, AIO, AIOLOS, ZNFN1A3, aio, aiolos, znfn1a3
Epitope
N-Term
(9), (8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(54), (26), (17), (15), (14), (14), (12), (2), (1), (1), (1)
Host
Rabbit
(42), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(42), (25), (10), (8), (7), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN183749
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human IKZF3
Sequence KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV
Predicted Reactivity Human : 100 %, Bovine : 80 %, Mouse : 80 %, Rabbit : 80 %, Rat : 70 %
Characteristics This is a rabbit polyclonal antibody against IKZF3. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name IKZF3
Background IKZF3 is a member of the Ikaros family of zinc-finger proteins. It is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoetic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
Molecular Weight 52 kDa
Gene ID 22806
NCBI Accession NM_183228, NP_899051
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 453 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (N-Term) antibody WB Suggested Anti-IKZF3 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (N-Term) antibody (2) anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (N-Term) antibody (Image 2)
Background publications Koipally, Georgopoulos: "A molecular dissection of the repression circuitry of Ikaros." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 27697-705, 2002 (PubMed).

Validation Images
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