Poly(rC) Binding Protein 4 (PCBP4) antibody

Antigen: Poly(rC) Binding Protein 4 (PCBP4)

Synonyms: LIP4, MCG10, AlphaCP-4, 1200003L19Rik, Pcbp4, zgc:77347, wu:fc68f03, PCBP4, MGC140586

Clonality: Polyclonal

Host: Rabbit

Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN184052

Additional Information

Alternative name: PCBP4

Description: PCBP4 is a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M.This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. Keywords: PCBP4, poly(rC) binding protein 4, ARP40944_P050, NP_065151, NP_127501, NP_127502, NP_127503, NM_020418, NM_033008, NM_033009, NM_033010, Q9GZT1, LIP4, MCG10

Application Details

Application Notes: ELISA titre: 1:62500 . Western Blotting: Suggested dilution at 0.25 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody.

Restrictions: For Research Use only

Images

anti-Poly(rC) Binding Protein 4 (PCBP4) antibody

Publications

Publications: Chkheidze, Liebhaber: "A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins." in: Molecular and cellular biology, Vol. 23, Issue 23, pp. 8405-15, 2003 (PubMed).