Dyslexia Susceptibility 1 Candidate 1 (DYX1C1) (Isoform A) antibody

Antigen: Dyslexia Susceptibility 1 Candidate 1 (DYX1C1)

Synonyms: RD, DYX1, EKN1, DYXC1, FLJ37882, MGC70618, 1700010I24Rik, Ekn1, Edem2, MGC94521, dyx1c1, MGC77853, DYX1C1, MGC83582, LOC100220614

Epitope: Isoform A

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN185356

Additional Information

Alternative name: DYX1C1 (Isoform a)

Gene ID: 161582, 67685 (mouse)

Immunogen: C-KIRNVIQGTELKS

Format: Affinity-purified

Description: All names and symbols: DYX1C1, DYX1, EKN1, DYXC1, FLJ37882, dyslexia susceptibility 1 candidate 1. Official Symbol: DYX1C1. RefSeq number(s): NP_570722.2. Gene ontology terms: binding, nucleus, Dyslexia

Specificity: This antibody is expected to recognise only one of the three reported isoforms (NP_570722.2, isoform a). Human, Mouse, Rat, Chimpanzee 420 aa

Application Details

Application Notes: Peptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: lysates of COS1 transfected with full length recombinant Human DYX1C1 gave bands at approx 48kDa after 0.1µg/ml antibody staining. In addition, a minor band of 24kDa is detected consistent with observations with N-terminal specific antibodies (unpublished data, LoTurco, Connecticut, USA). The 75kDa band is visible in the non-transfected COS1 also (first lane) and is therefore non-specific. We call for caution when this product is used in other assays than Western blot. Data kindly provided by Wang and LoTurco, University of Connecticut, USA.

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Storage: Aliquot and store at -20°C. Minimize freezing and thawing.

Restrictions: For Research Use only

Images

ABIN185356 staining (0.1µg/ml) of COS1 cell lysates: untransfected (left lane) and transfected with full length recombinant Human DYX1C1 (right lane). Data kindly provided by Wang and LoTurco, University of Connecticut, USA.

Publications

Publications: Taipale, Kaminen, Nopola-Hemmi et al.: "A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11553-8, 2003 (PubMed).