Solute Carrier Family 6 Member 4 (SLC6A4) antibody

Antigen: Solute Carrier Family 6 Member 4 (SLC6A4)

Synonyms: HTT, 5HTT, OCD1, SERT, 5-HTT, hSERT, 5-HTTLPR, Htt, Sert, AI323329, MGC124313, MGC124314

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN185394

Additional Information

Alternative name: SLC6A4 / 5HTT / SERT

Gene ID: 6532

Immunogen: C-LHQGERETWGK

Format: Affinity-purified

Description: All names and symbols: SLC6A4, SERT, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , HGNC:11050, 5-HTT, HTT, OCD1, hSERT , 5-hydroxytryptamine transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, serotonin transporter, sodium-dependent serotonin transporter, solute carrier family 6 member 4. Official Symbol: SLC6A4. RefSeq number(s): NP_001036.1. Gene ontology terms: Attention-deficit hyperactivity disorder (ADHD). Transporter of serotonin, Myocardial Infarction

Specificity: Human

Application Details

Application Notes: Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 70-75kDa bands observed in Human Duodenum lysates (calculated MW of 70.3kDa according to NP_001036.1). Recommended concentration: 1-3µg/ml.

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Storage: Aliquot and store at -20°C. Minimize freezing and thawing.

Restrictions: For Research Use only

Images

ABIN185394 staining (1µg/ml) of Human Duodenum lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Publications

Publications: Voeller: "Attention-deficit hyperactivity disorder (ADHD)." in: Journal of child neurology, Vol. 19, Issue 10, pp. 798-814, 2004 (PubMed).

Wolff, Grabe, Voelzke et al.: "A functional serotonin transporter (SLC6A4) polymorphism modifies the association of smoking and diabetes with asymptomatic carotid atherosclerosis." in: Thrombosis and haemostasis, Vol. 93, Issue 1, pp. 180-2, 2005 (PubMed).

Curran, Purcell, Craig et al.: "The serotonin transporter gene as a QTL for ADHD." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 134B, Issue 1, pp. 42-7, 2005 (PubMed).