SLC6A4 antibody (AA 401-500)

Catalog No. ABIN735983

Product Details anti-SLC6A4 Antibody

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Binding Specificity: AA 401-500

Reactivity: Human, Rat, Mouse, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Chicken, Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 5-HTT

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SLC6A4 antibody (ABIN735983)

Yu, Huang, Zhang, Ye, Chi, Zou, Lv, Zheng: "Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis." in: World journal of gastroenterology, Vol. 22, Issue 12, pp. 3451-9, (2016) (PubMed).

Wang, Gu, Liu, Bai, Wang: "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." in: Molecular medicine reports, Vol. 15, Issue 2, pp. 673-680, (2016) (PubMed).

Wojtal, Cee, Lang, Götze, Frühauf, Geier, Pastor-Anglada, Torres-Torronteras, Martí, Fried, Lutz, Maggiorini, Gassmann, Rogler, Vavricka: "Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 7, pp. G673-88, (2014) (PubMed).

Wang, Liu, Wang, Bai, Zhang, Sun, Wang: "Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats." in: Human & experimental toxicology, (2013) (PubMed).

Dong, Li, Zheng, Mu, Zhang, Liu: "A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats." in: Journal of ethnopharmacology, Vol. 150, Issue 3, pp. 1053-61, (2013) (PubMed).

Bai, Wang, Liu, Wang, Lian, Zhang, Kang, Wang: "4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation." in: International journal of molecular medicine, Vol. 33, Issue 2, pp. 373-82, (2013) (PubMed).

Target Details for SLC6A4

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Alternative Name: SLC6A4/5-HTT (SLC6A4 Products)

Synonyms: 5-HTT antibody, 5-HTTLPR antibody, 5HTT antibody, HTT antibody, OCD1 antibody, SERT antibody, SERT1 antibody, hSERT antibody, AI323329 antibody, Htt antibody, Sert antibody, CG4545 antibody, DmSERT antibody, DmSerT antibody, Dmel\\CG4545 antibody, dSERT antibody, dSERT1 antibody, dSerT antibody, dSert antibody, dsert antibody, SLC6A4 antibody, solute carrier family 6 member 4 antibody, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 antibody, Serotonin transporter antibody, huntingtin antibody, solute carrier family 6 (neurotransmitter transporter), member 4b antibody, solute carrier family 6 (neurotransmitter transporter), member 4a antibody, SLC6A4 antibody, Slc6a4 antibody, SerT antibody, LOC100540532 antibody, slc6a4 antibody, slc6a4b antibody, slc6a4a antibody

Background:

Synonyms: HTT, 5HTT, OCD1, SERT, 5-HTT, SERT1, hSERT, 5-HTTLPR, Sodium-dependent serotonin transporter, 5HT transporter, Solute carrier family 6 member 4, SLC6A4

Background: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Gene ID: 6532

UniProt: P31645