Cyclin B3 antibody (pThr280)

Catalog No. ABIN1881173

The Rabbit Polyclonal anti-Cyclin B3 antibody has been validated for DB. It is suitable to detect Cyclin B3 in samples from Human. There are 3+ publications available.

Quick Overview for Cyclin B3 antibody (pThr280) (ABIN1881173)

Target: Cyclin B3 (CCNB3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin B3 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB42155

Product Details anti-Cyclin B3 Antibody

Binding Specificity: pThr280

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCNB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T280 of human CCNB3.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Cyclin B3 antibody (ABIN1881173)

Cheng, Kapranov, Drenkow, Dike, Brubaker, Patel, Long, Stern, Tammana, Helt, Sementchenko, Piccolboni, Bekiranov, Bailey, Ganesh, Ghosh, Bell, Gerhard, Gingeras: "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution." in: Science (New York, N.Y.), Vol. 308, Issue 5725, pp. 1149-54, (2005) (PubMed).

Mouland, Coady, Yao, Cohen: "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression." in: Virology, Vol. 292, Issue 2, pp. 321-30, (2002) (PubMed).

Nguyen, Manova, Capodieci, Lindon, Bottega, Wang, Refik-Rogers, Pines, Wolgemuth, Koff: "Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41960-9, (2002) (PubMed).

Target Details for Cyclin B3

Target: Cyclin B3 (CCNB3)

Alternative Name: CCNB3

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chick and Drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 157916

NCBI Accession: NP_149020, NP_391990

UniProt: Q8WWL7

Pathways: Cell Division Cycle, Chromatin Binding