COLQ antibody (C-Term)

Catalog No. ABIN1881222

Cited in 3+ publications. The Rabbit Polyclonal anti-COLQ antibody (Clone RB30589) (ABIN1881222) specifically detects COLQ in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for COLQ antibody (C-Term) (ABIN1881222)

Target: COLQ (AChE Q Subunit (COLQ))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COLQ antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB30589

Product Details anti-COLQ Antibody

Binding Specificity: AA 324-353, C-Term

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COLQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-353 amino acids from the C-terminal region of human COLQ.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-COLQ antibody (ABIN1881222)

Mihaylova, Müller, Vilchez, Salih, Kabiraj, DAmico, Bertini, Wölfle, Schreiner, Kurlemann, Rasic, Siskova, Colomer, Herczegfalvi, Fabriciova, Weschke, Scola, Hoellen, Schara, Abicht, Lochmüller: "Clinical and molecular genetic findings in COLQ-mutant congenital myasthenic syndromes." in: Brain : a journal of neurology, Vol. 131, Issue Pt 3, pp. 747-59, (2008) (PubMed).

Schreiner, Hoppenz, Klaeren, Reimann, Woelfle: "Novel COLQ mutation 950delC in synaptic congenital myasthenic syndrome and symptomatic heterozygous relatives." in: Neuromuscular disorders : NMD, Vol. 17, Issue 3, pp. 262-5, (2007) (PubMed).

Ishigaki, Nicolle, Krejci, Leroy, Koenig, Fardeau, Eymard, Hantaï: "Two novel mutations in the COLQ gene cause endplate acetylcholinesterase deficiency." in: Neuromuscular disorders : NMD, Vol. 13, Issue 3, pp. 236-44, (2003) (PubMed).

Target Details for COLQ

Target: COLQ (AChE Q Subunit (COLQ))

Alternative Name: COLQ

Background: This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 47766

NCBI Accession: NP_005668, NP_536799, NP_536800

UniProt: Q9Y215