LRRC8A antibody (C-Term)

Catalog No. ABIN1881512

Product Details anti-LRRC8A Antibody

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Binding Specificity: AA 782-810, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC8A antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LRRC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782-810 amino acids from the C-terminal region of human LRRC8A.

Clone: RB30632

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LRRC8A antibody (ABIN1881512)

Smits, Kajava: "LRRC8 extracellular domain is composed of 17 leucine-rich repeats." in: Molecular immunology, Vol. 41, Issue 5, pp. 561-2, (2004) (PubMed).

Conley: "Genes required for B cell development." in: The Journal of clinical investigation, Vol. 112, Issue 11, pp. 1636-8, (2003) (PubMed).

Target Details for LRRC8A

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Alternative Name: LRRC8A (LRRC8A Products)

Background: This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Molecular Weight: 94199

NCBI Accession: NP_001120716, NP_001120717, NP_062540

UniProt: Q8IWT6