POU2AF1
Reactivity: Human
WB
Host: Mouse
Monoclonal
7C1
unconjugated
Application Notes
WB: 1:4000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Galiègue-Zouitina, Quief, Hildebrand, Denis, Lecocq, Collyn-dHooghe, Bastard, Yuille, Dyer, Kerckaert: "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation." in: Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie, Vol. 318, Issue 11, pp. 1125-31, (1996) (PubMed).
Luo, Roeder: "Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B." in: Molecular and cellular biology, Vol. 15, Issue 8, pp. 4115-24, (1995) (PubMed).
Target
POU2AF1
(POU Class 2 Associating Factor 1 (POU2AF1))
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.