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CAMK2A/B (pThr286) antibody
| Antigen | CAMK2A/B |
| Epitope |
pThr286 |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human |
| Application |
Immunofluorescence (IF), Western Blotting (WB)
|
| Catalog no. | ABIN197055 |
| Quantity | 50 µg (1.0 mg/ml) |
| Price | 240.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Synonyms: CAMKA, KIAA0968, CaM-kinase II alpha chain, CaM kinase II subunit alpha, CaMK-IIsubunit alpha, Calcium/calmodulin-dependent protein kinase type II alpha chain |
| Swiss-Prot | Q9UQM7 |
| Immunogen | The antiserum was produced against synthesized phosphopeptide derived from HumanCaMKII around the phosphorylation site of Threonine 286 (Q-E-Tp-V-D). |
| Cross-Reactivity | Human, Mouse (Murine), Rat (Rattus) |
| Description | CaMKII (Calcium/calmodulin-dependent protein kinase II) is a ubiquitous serine/threonineprotein kinase that is abundant in the brain as a major constituent of the postsynapticdensity (PSD). The enzyme is an oligomeric protein composed of distinct but relatedsubunits, alpha, beta, gamma, and delta, each encoded by a separate gene. CAMK2Aassembles into heterooligomeric complexes with other CAMK2 subunits. CaMKII is a prominent kinase in the central nervous system that may function in long termpotentiation and neurotransmitter release. |
| Specificity | This antibody detects endogenous levels of CaMKII only when phosphorylated at Threonine286. Species: Human, Mouse and Rat. Others not tested. |
Application Details
| Application Notes | Western Blot: 1/500~1/1000. Incubate membrane with diluted antibody in 5% nonfat milk, 1X TBS, 0.1% Tween-20 at 4°Cwith gentle shaking, overnight. Immunofluorescence: 1/100~1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
| Concentration | 1.0 mg/ml |
| Purification | Aff - Purified |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02%Sodium Azide and 50% Glycerol. |
| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Restrictions | For Research Use only |
