APH1B antibody (N-Term)

Catalog No. ABIN2156383

Product Details anti-APH1B Antibody

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Binding Specificity: N-Term

Reactivity: Mouse, Human, Rat, Rabbit, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APH1B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IIDNKDGPTQ KYLLIFGAFV SVYIQEMFRF AYYKLLKKAS EGLKSINPGE

Predicted Reactivity: Cow: 92%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against APH1B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human APH1B

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for APH1B

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Alternative Name: APH1B (Aph1b Products)

Background: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
Alias Symbols: APH-1B, PRO1328, PSFL, TAAV688
Protein Interaction Partner: UBC, PSENEN, NCSTN, PSEN2, PSEN1,
Protein Size: 257

Molecular Weight: 28 kDa

Gene ID: 83464

NCBI Accession: NM_031301, NP_112591

UniProt: Q8WW43

Pathways: Notch Signaling, Neurotrophin Signaling Pathway