SNCA antibody

Catalog No. ABIN236423

The Mouse Monoclonal anti-SNCA antibody has been validated for WB, ELISA, IHC (p) and IHC (f). It is suitable to detect SNCA in samples from Human.

Quick Overview for SNCA antibody (ABIN236423)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: 4D6

Product Details anti-SNCA Antibody

Specificity: Reacts well with alpha-synuclein in Western blots and frozen and formalin-fixed/paraffin-embedded tissue sections. Recognizes human alpha-synuclein. Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.

Characteristics: MAb to Synuclein Alpha, Monoclonal antibody to Human Synuclein alpha, Tissue culture supernatant

Purification: Protein A column Chromatography. Cell culture

Immunogen: Purified E. coli produced human alpha-synuclein

Isotype: IgG1

Application Details

Application Notes: Western/Dot blot (1:100 - 1:10.000) ELISA Immunohistochemistry: (1:100 - 1:1.000) frozen and formalin-fixed paraffin-embedded tissues (No formic acid, enzyme or HIER required). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS.

Preservative: Without preservative

Handling Advice: Avoid multiple freeze/thaw cycles.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.

Storage: -20 °C

Storage Comment: Store at -20 °C.

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: Synuclein alpha

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity