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Death-Domain Associated Protein (DAXX) antibody

Antigen

Death-Domain Associated Protein (DAXX)
Synonyms DAP6, EAP1, BING2, MGC126245, MGC126246, MGC150289, DAP-3, 4921514D13Rik, im:6905684, LOC100226911
Clonality Monoclonal (DAXX-03)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Application
Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Catalog no. ABIN238399
Quantity 0.1 mg  (1.0 mg/ml)
Price 265.00 $   Plus shipping costs $35.00
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Availability Ships within 7 to 10 Business Days

Additional Information
Application Details Alternatives Secondary Antibodies back to top

Characteristics Synonyms: BING2, DAP6, EAP1, Death domain-associated protein 6, Fas death domain-associatedprotein, ETS1-associated protein 1
Alternative name DAXX
Swiss-Prot Q9UER7
Immunogen His6-tagged protein corresponding to amino acids 580-740 of human Daxx.
Cross-Reactivity Human
Isotype IgG1  (Matching secondary antibodies)
Clone DAXX-03
Description Daxx is an apoptosis-modulating death-domain associated protein with functions intranscriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, andin nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependentregulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cellsto apoptosis, but on the other hand, this protein may also serve in preventing apoptosis inthe early embryo. Even regarding the transcription, Daxx can serve both as a corepressorand a coactivator. During ischemic stress, Daxx translocates from the nucleus to thecytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
Specificity The antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein. Species: Human. Others not tested.

Application Details
Alternatives Secondary Antibodies back to top

Application Notes Immunoprecipitation. Western Blotting (2 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 1.0 mg/ml
Purification Aff - Purified
Buffer PBS, pH 7.4 with 15 mM sodium azide as preservative.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles. Shelf life: One year from despatch.
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies back to top

Alternatives for antigen "Death-Domain Associated Protein (DAXX)", type "Antibodies"
Hosts Rabbit (56), Mouse (16)
Reactivities Human (71), Mouse (Murine) (31), Rat (Rattus) (26), Cow (Bovine) (19), Dog (Canine) (16), Pig (Porcine) (16), Rabbit (16), Sheep (Ovine) (15), Monkey (5), Horse (Equine) (1)
Applications Western Blotting (WB) (51), Immunofluorescence (IF) (32), Flow Cytometry (FACS) (22), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), ELISA (14), Enzyme Immunoassay (EIA) (13), Immunoprecipitation (IP) (7), Immunocytochemistry (ICC) (6), Immunohistochemistry (IHC) (6), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Dot Blot (Dot) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Detection) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 488 (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes C-Term (6), S495 (2), pSer213 (2), pSer495 (2), pSer517 (2), pSer671 (2), AA 272-291 (1), AA 561- 661 (1), S213 (1), S517 (1), pS671 (1)