DAXX antibody

Catalog No. ABIN969493

Product Details anti-DAXX Antibody

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human DAXX expressed in E. coli.

Clone: 7A11

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50 % glycerol and 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: DAXX (DAXX Products)

Synonyms: BING2 antibody, DAP6 antibody, EAP1 antibody, LOC100226911 antibody, daxx antibody, si:dz179b20.7 antibody, wu:fd15c03 antibody, death domain associated protein antibody, Fas death domain-associated protein antibody, 28S ribosomal protein S29, mitochondrial antibody, death-domain associated protein antibody, death-associated protein 6 L homeolog antibody, DAXX antibody, Daxx antibody, LOC100226911 antibody, daxx.L antibody, daxx antibody

Background:

Description: DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Aliases: DAP6, EAP1, BING2

Molecular Weight: 81 kDa

Gene ID: 1616

HGNC: 1616

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway