Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody (FITC)

Antigen: Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2)

Synonyms: C3DR, CD21, SLEB9

Clonality: Monoclonal (LT21)

Host: Mouse

Reactivity: Cow (Bovine)

Conjugate: FITC

Application: Flow Cytometry (FACS)

Catalog no.: ABIN238433

Additional Information

Characteristics: Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic CellMarker, Complement C3d receptor, Epstein-Barr virus receptor

Alternative name: CD21

Swiss-Prot: P20023

Immunogen: IM9 human B-lymphoblastoid cell line

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Pig (Porcine)

Isotype: IgG1

Clone: LT21

Description: CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially itsbreakdown fragments, which remain covalently attached to complement activatingsurfaces or antigen. CD21 has important roles in uptake and retention ofimmunocomplexes, survival of memory B cells and in development and maintenance of thehumoral response to T-dependent antigens. CD21 also serves as a key receptor forEpstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells andexpediting neuroinvasion following peripheral exposure to prions. A soluble form of theCD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respectiveligands.

Specificity: The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein(complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells,some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature Bcells. Species: Human, Porcine, Bovine, canine. Others not tested.

Application Details

Application Notes: Suitable for Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl ofwhole blood or 10e6 cells in a suspension. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2% (w/v)high-grade BSA (Protease free) as stabilizer.Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions.

Storage: Store the antibody in the dark at 2-8°C. Do Not Freeze! Avoid prolonged exposure to light. Shelf life: one year from despatch.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only