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Antibodies
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anti-Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody
Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) antibody
| Antigen |
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| Synonyms |
C3DR, CD21, SLEB9 |
| Clonality |
Monoclonal (LT21) |
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Host
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Reactivity
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Application
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 Alternatives Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
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| Catalog no. |
ABIN238434 |
| Quantity |
0.1 mg (1.0 mg/ml) |
| Price |
265.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic CellMarker, Complement C3d receptor, Epstein-Barr virus receptor
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Alternative name
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CD21
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Swiss-Prot
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P20023
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Immunogen
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IM9 human B-lymphoblastoid cell line
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Cross-Reactivity
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Cow (Bovine), Dog (Canine), Human, Pig (Porcine)
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Isotype
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IgG1 (Matching secondary antibodies)
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Clone
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LT21
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Description
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CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially itsbreakdown fragments, which remain covalently attached to complement activatingsurfaces or antigen. CD21 has important roles in uptake and retention ofimmunocomplexes, survival of memory B cells and in development and maintenance of thehumoral response to T-dependent antigens. CD21 also serves as a key receptor forEpstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells andexpediting neuroinvasion following peripheral exposure to prions. A soluble form of theCD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respectiveligands.
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Specificity
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The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein(complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells,some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature Bcells. Species: Human, Porcine, Bovine, Canine. Others not tested.
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Application Notes
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Suitable for Flow Cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Concentration
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1.0 mg/ml
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Purification
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Purified
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Buffer
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PBS, pH 7.4 containing 15 mM sodium azide as preservative.
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Storage
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Research Area
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CD Antigens, Surface Receptors of Immune Cells
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Restrictions
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For Research Use only
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Alternatives for antigen "Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2)", type "Antibodies"
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Hosts
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Mouse (78), Rabbit (2)
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Reactivities
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Human (55), Pig (Porcine) (18), Cow (Bovine) (17), Dog (Canine) (11), Horse (Equine) (5), Goat (4), Sheep (Ovine) (4), Cat (Feline) (3)
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Applications
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Flow Cytometry (FACS) (53), Immunohistochemistry (Frozen Sections) (IHC (fro)) (17), Immunoprecipitation (IP) (14), Immunohistochemistry (IHC) (11), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunocytochemistry (ICC) (4), Western Blotting (WB) (3), ELISA (1), Immunofluorescence (IF) (1)
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Conjugates
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FITC (17), PE (9), Biotin (7), RPE (4), Pacific Blue (1)
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Epitopes
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C-Term (1)
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