Membrane Metallo Endopeptidase (MME) antibody (APC)

Antigen: Membrane Metallo Endopeptidase (MME)

Synonyms: NEP, CD10, CALLA, MGC126681, MGC126707, DKFZp686O16152, C85356, 6030454K05Rik, MME, Neprilysin, DKFZp469N0914

Clonality: Monoclonal (MEM-78)

Host: Mouse

Reactivity: Human

Conjugate: APC

Application: Flow Cytometry (FACS)

Catalog no.: ABIN238477

Additional Information

Alternative name: CD10 / Neprilysin

Swiss-Prot: P08473

Immunogen: NALM-6 human pre-B cell line

Cross-Reactivity: Human

Isotype: IgG1

Clone: MEM-78

Description: CD10 (neutral endopeptidase - NEP, common acute lymphocytic leukemia antigen - CALLA, membrane metallo-endopeptidase - MME, enkefalinase) is a 100-kDa cell surface zinc metalloprotease cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems. Alternate Names: MME, EPN, CD10, CALLA, EC 3.4.24.11, Neutral endopeptidase 24.11, Neutral endopeptidase, NEP, Atriopeptidase, Common acute lymphocytic leukemia antigen.

Specificity: The antibody MEM-78 reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.

Application Details

Application Notes: for Flow Cytometry analysis of human blood cells using 10 m l reagent / 100 m l of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2% (w/v) high-grade BSA (Protease free) as stabilizer

Storage: Store the antibody in the dark at 2-8°C. Do Not Freeze! Avoid prolonged exposure to light. Shelf Life: one year from despatch.

Research Area: CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only