Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term) antibody

Details for Product No. ABIN264872
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Synonyms Rsk1, p90rsk, rsk, HU-1, MAPKAPK1A, RSK, RSK1, RPS6KA, hu-1, mapkapk1a, rsk1, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2
(33), (21), (20), (20), (17), (10), (9), (8), (7), (7), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(220), (88), (74), (43), (42), (36), (27), (5), (2)
(208), (27)
(12), (12), (10), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4)
ELISA, Immunoprecipitation (IP), Western Blotting (WB)
(175), (95), (52), (45), (40), (29), (21), (18), (12), (3)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN264872
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Immunogen Human p90 RSK1 C-terminal peptide, conjugated to KLH
Isotype IgG
Specificity This antibody detects an ~90kDa protein, corresponding to the molecular mass of p90 RSK1 on SDS-PAGE immunoblots.
Purification Affinity Chromatography
Alternative Name RPS6KA1
Background The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk1-4). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signalregulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
Alternate names: 90 kDa ribosomal protein S6 kinase 1, MAPKAPK1A, RSK-1, RSK1, Ribosomal S6 kinase 1, Ribosomal protein S6 kinase alpha-1, p90RSK1
Gene ID 6195
NCBI Accession NP_001006666
UniProt Q15418
Research Area Signaling
Application Notes Western blot (0.25 ug/ml). Immunoprecipitation. ELISA. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer TBS 0.09% Sodium Azide 50% Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term) antibody anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term) antibody
Background publications Joel, Smith, Sturgill et al.: "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1978-84, 1998 (PubMed).

De Cesare, Jacquot, Hanauer et al.: "Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 21, pp. 12202-7, 1998 (PubMed).

Merienne, Jacquot, Trivier et al.: "Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome." in: Journal of medical genetics, Vol. 35, Issue 11, pp. 890-4, 1999 (PubMed).

Frödin, Gammeltoft: "Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction." in: Molecular and cellular endocrinology, Vol. 151, Issue 1-2, pp. 65-77, 1999 (PubMed).

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