Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) antibody

Details for Product No. ABIN265256
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Antigen
Synonyms fj65d02, zgc:63982, wu:fj65d02, flap, al5ap, Alox5ap, ALOX5AP, Flap, FLAP
Reactivity
Human
(30), (4)
Host
Rabbit
(16), (15)
Clonality
Polyclonal
Application
Western Blotting (WB)
(25), (15), (15), (3)
Pubmed 2 references available
Quantity 1 vial
Quantity Comment 10 blots
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN265256
500.50 $
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Immunogen Synthetic peptide derived from Human FLAP protein
Specificity This antibody detects FLAP.
Purification Antigen Immunoaffiinity Chromatography
Alternative Name ALOX5AP / FLAP
Background Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367], also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Alternate names: Arachidonate 5-lipoxygenase-activating protein, MK-886-binding protein
Cellular Localization: Nucleus membrane. Endoplasmic reticulum membrane.
Gene ID 241
NCBI Accession NP_001191335
UniProt P20292
Application Notes Western blot (1: 400 starting dilution). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.08% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C. Can be shipped at 2-8 °C.
Expiry Date 12 months
Supplier Images
anti-Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) antibody anti-Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) antibody
Background publications Dixon, Diehl, Opas et al.: "Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis." in: Nature, Vol. 343, Issue 6255, pp. 282-4, 1990 (PubMed).

Helgadottir, Manolescu, Thorleifsson et al.: "The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke." in: Nature genetics, Vol. 36, Issue 3, pp. 233-9, 2004 (PubMed).

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