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Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) antibody

Details for Product No. ABIN265257, Supplier: Log in to see
Antigen
  • fj65d02
  • zgc:63982
  • wu:fj65d02
  • flap
  • al5ap
  • Alox5ap
  • ALOX5AP
  • Flap
  • FLAP
Reactivity
Human
58
6
3
2
2
1
1
Host
Rabbit
38
22
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
51
34
20
18
5
Supplier
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Immunogen Synthetic peptide derived from Human FLAP protein
Specificity This antibody detects FLAP.
Cellular Localization: Nucleus membrane. Endoplasmic reticulum membrane.
Purification Ammonium Sulfate Precipitation
Alternative Name ALOX5AP / FLAP (ALOX5AP Antibody Abstract)
Background Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367], also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.Synonyms: Arachidonate 5-lipoxygenase-activating protein, MK-886-binding protein
Gene ID 241
NCBI Accession NP_001191335
UniProt P20292
Pathways
Application Notes Western blot (1-5 g).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS with 0.08 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C.
Supplier Images
 image for anti-Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) antibody (ABIN265257) anti-Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) antibody
Background publications Helgadottir, Manolescu, Thorleifsson et al.: "The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. ..." in: Nature genetics, Vol. 36, Issue 3, pp. 233-9, 2004 (PubMed).

Dixon, Diehl, Opas et al.: "Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis." in: Nature, Vol. 343, Issue 6255, pp. 282-4, 1990 (PubMed).