Zinc Finger Protein GLI1 (GLI1) antibody

Details for Product No. ABIN265275
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Antigen
Synonyms GLI, Gli, Gli-1, gli1.1, AV235269, Zfp-5, Zfp5
Reactivity
Human
(44), (19), (15), (15), (13), (6), (1), (1)
Host
Rabbit
(43), (7), (4), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(39), (19), (10), (7), (6), (6), (3), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN265275
368.50 $
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Immunogen Synthetic peptide derived from human zinc finger protein GLI1
Specificity Thia antibody detects Zinc Finger Protein GLI1, found in testis, myometrium and fallopian tube.
Purification Purified
Alternative Name GLI1
Background Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes dring normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.
Alternate names: GLI, GLI-1, Glioma-associated oncogene, Oncogene GLI, Zinc finger protein GLI1
Gene ID 2735
NCBI Accession NP_001153517
UniProt P08151
Research Area Growth Factors
Application Notes Western blot (1: 400 starting dilution). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline with 0.08% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Expiry Date 12 months
Background publications Kinzler, Ruppert, Bigner et al.: "The GLI gene is a member of the Kruppel family of zinc finger proteins." in: Nature, Vol. 332, Issue 6162, pp. 371-4, 1988 (PubMed).

Wang, Chan, Rothnagel: "Letters to the editor: identification of polymorphic variants of the GLI1 oncogene." in: The Journal of investigative dermatology, Vol. 115, Issue 2, pp. 328-9, 2000 (PubMed).

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