Glutamate Receptor, Metabotropic 7 (GRM7) antibody

Antigen: Glutamate Receptor, Metabotropic 7 (GRM7)

Synonyms: GLUR7, MGLU7, GPRC1G, MGLUR7, FLJ40498, Gpr1g, Gprc1g, mGluR7, BB176677, MGC90857, C030018L03, 6330570A01Rik, E130018M02Rik, GRM7, MGC151963, DKFZp459P0826

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN265440

Additional Information

Characteristics: Synonyms: Metabotropic glutamate receptor 7, GPRC1G, MGLUR7

Alternative name: MGluR7 / GRM7

Gene ID: 2917

Swiss-Prot: Q14831

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Description: The mGluR proteins (metabotropic glutamate receptors) are members of the Gprotein-coupled receptor family and are functionally and pharmacologically distinct fromthe GluR proteins (ionotropic glutamate receptors). The eight currently known mGluRproteins are mediated by two G proteins with opposing regulation of adenylate cyclasepathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activatesa phosphatidylinositolcalcium second messenger system and generates acalcium-activated chloride current. The remainder of the eight subtypes of mGluR have anactivity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-7, whichcan interact with PRKCABP, acts as a receptor for glutamate. It is highly expressed invarious areas of the brain, but highest levels are detected in cerebellum, cerebral cortexand hippocampus.

Specificity: This antibody detects endogenous levels of mGluR7 protein. Species: Human, Mouse, Rat. Others not tested.

Application Details

Application Notes: ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry: 1/50-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: Phosphate Buffered Saline (PBS), pH~7.2 with 15 mM Sodium Azide aspreservative

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only