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- Target See all ABCB1 Antibodies
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ABCB1 antibody is conjugated to PE
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Application
- Immunochromatography (IC), Intracellular Flow Cytometry (ICFC)
- Purification
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Clone
- UIC2
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product ABCB1 Primary Antibody
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anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 621-650), (Middle Region) antibody
ABCB1 Reactivity: Human, Mouse, Rat IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 995-1280) antibodyABCB1 Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 2C7 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 995-1280) antibodyABCB1 Reactivity: Human IHC, IHC (p) Host: Mouse Monoclonal 5B3 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) antibodyABCB1 Reactivity: Human WB, IHC Host: Rabbit Monoclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 236-297) antibodyABCB1 Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 1149-1280) antibodyABCB1 Reactivity: Human ELISA, FACS Host: Mouse Monoclonal 4G6F4 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibodyABCB1 Reactivity: Human ELISA Host: Mouse Monoclonal 6G11C12 unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 863-912) antibodyABCB1 Reactivity: Human, Mouse, Rat, Rabbit, Hamster WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (Middle Region) antibodyABCB1 Reactivity: Human, Mouse, Rat, Dog, Rabbit, Horse, Zebrafish (Danio rerio), Sheep, Pig, Guinea Pig, Cow WB, IHC Host: Rabbit Polyclonal unconjugated
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 647-677) antibodyABCB1 Reactivity: Human WB Host: Rabbit Polyclonal RB2208 unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
- Alternative Name
- CD243 (ABCB1 Products)
- Background
- CD243 (MDR-1) belongs to the ATP binding cassette (ABC) transporter family. With an approximate molecular mass of 170 kD, it consists of two homologous halves. Each half contains two hydrophobic transmembrane domains (TMDs) and two hydrophilic nucleotide binding domains (NBDs). The TMDs span the membrane six times, forming a chamber with a 12 transmembrane α-helix structure. NBDs drive the transport process through ATP coupling and hydrolysis and are located at the cytoplasmic face of the membrane. CD243 transports various molecules across cellular membranes and is involved in multidrug resistance. MDR-1 is expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells. CD243 interacts with Caveolin, RING finger protein 1B, AAP1, p53, Orphan nuclear receptor PX, and cytochrome P450.
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