ABCB1 antibody (AA 632-693)
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- Target See all ABCB1 Antibodies
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
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Binding Specificity
- AA 632-693
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ABCB1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human ABCB1 (AA: 632-693) expressed in E. coli.
- Clone
- 6G11C12
- Isotype
- IgG1
- Top Product
- Discover our top product ABCB1 Primary Antibody
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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Study of ABCB1 polymorphism frequency in breast cancer patients from Poland." in: Pharmacological reports : PR, Vol. 64, Issue 6, pp. 1560-6, (2013) (PubMed).
: "Downregulation of gene MDR1 by shRNA to reverse multidrug-resistance of ovarian cancer A2780 cells." in: Journal of cancer research and therapeutics, Vol. 8, Issue 2, pp. 226-31, (2012) (PubMed).
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Study of ABCB1 polymorphism frequency in breast cancer patients from Poland." in: Pharmacological reports : PR, Vol. 64, Issue 6, pp. 1560-6, (2013) (PubMed).
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- Target
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
- Alternative Name
- ABCB1 (ABCB1 Products)
- Synonyms
- ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1a antibody, p-gp antibody, xemdr antibody, Mdr1 antibody, Mdr1b antibody, Pgy-1 antibody, Pgy1 antibody, mdr antibody, ABCB1 antibody, PGP1 antibody, ATP binding cassette subfamily B member 1 antibody, ATP binding cassette subfamily B member 1A antibody, ATP binding cassette subfamily B member 1 L homeolog antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antibody, ABCB1 antibody, Abcb1a antibody, abcb1.L antibody, Abcb1b antibody, Abcb1 antibody
- Background
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Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. ,
Aliases: CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170
- Molecular Weight
- 141.5 kDa
- Gene ID
- 5243
- HGNC
- 5243
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