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- Target See all TLR3 Antibodies
- TLR3 (Toll-Like Receptor 3 (TLR3))
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This TLR3 antibody is conjugated to PE
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Purification
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Clone
- 11F8
- Isotype
- IgG2a
- Top Product
- Discover our top product TLR3 Primary Antibody
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anti-Toll-Like Receptor 3 (TLR3) (AA 404-532) antibody
TLR3 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 464-647) antibodyTLR3 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 801-905) antibodyTLR3 Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 24-217) antibodyTLR3 Reactivity: Human ELISA, FACS Host: Mouse Monoclonal 6F3G4 unconjugated
anti-Toll-Like Receptor 3 (TLR3) (C-Term) antibodyTLR3 Reactivity: Human WB, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 135-297) antibodyTLR3 Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 55-70) antibodyTLR3 Reactivity: Human, Monkey, Goat, Sheep WB, IHC, FACS, IP, IHC (p) Host: Mouse Monoclonal 40C1285-6 unconjugated
anti-Toll-Like Receptor 3 (TLR3) antibodyTLR3 Reactivity: Mouse FACS, IF Host: Rat Monoclonal 11F8 unconjugated
anti-Toll-Like Receptor 3 (TLR3) (C-Term) antibodyTLR3 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Toll-Like Receptor 3 (TLR3) (AA 750-800), (pTyr759) antibodyTLR3 Reactivity: Human WB, IHC, IHC (fro) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- TLR3 (Toll-Like Receptor 3 (TLR3))
- Alternative Name
- CD283 (TLR3 Products)
- Background
- Toll-like receptor 3 (TLR3), also known as CD283, is type I transmembrane protein that belongs to the TLR family. It forms a large horseshoe shape that contacts a neighboring horseshoe, forming a dimer of two horseshoes. It is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. TLR3 is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. It is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens by recognizing polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. Ligand binding by TLR3 induces receptor dimerization which results in inducing NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2.
- Pathways
- TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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