ATF6B antibody

Catalog No. ABIN272250

The Rabbit Polyclonal anti-ATF6B antibody (ABIN272250) specifically detects ATF6B in WB. The antibody is reactive with Human samples.

Quick Overview for ATF6B antibody (ABIN272250)

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF6B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATF6B Antibody

Specificity: This antibody detects endogenous levels of ATF-6β protein. (region surrounding Ser425)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for ATF6B

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Alternative Name: ATF6 beta

Background: ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6β homodimer or an ATF-6α/β heterodimer. Binding of the ATF-6β homodimer or ATF-6α/β heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription. Human ATF-6β maps to 1q22-q23 gene locus.Synonyms: ATF-6, Activating transcription factor 6 beta, CREBL1, Creb-rp, Cyclic AMP-dependent transcription factor ATF-6 beta, G13, Protein G13, cAMP response element-binding protein-related protein, cAMP-dependent transcription factor ATF-6 beta, cAMP-responsive element-binding protein-like 1

Molecular Weight: approx. 76 kDa

Gene ID: 1388

NCBI Accession: NP_001129625

UniProt: Q99941

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction