TACR3 antibody

Catalog No. ABIN298071

The Rabbit Polyclonal anti-TACR3 antibody (ABIN298071) specifically detects TACR3 in WB, IHC and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for TACR3 antibody (ABIN298071)

Target: TACR3 (Tachykinin Receptor 3 (TACR3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TACR3 Antibody

Specificity: Recognizes human TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kD multi-pass membrane protein belonging to the G-protein coupled receptor 1 family. TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. Studies with mice indicate that TACR3 is involved in learning and memory. AHP1492 does not recognize NK1R or NK2R.

Purification: Affinity purified

Immunogen: An 18 amino acid peptide from near the center of human TACR3.

Application Details

Application Notes: Approved: IHC, IHC-P (5 μg/mL), WB (0.5 - 1 μg/mL)

Usage: Western Blot: LS-C56946 detects a band of approximately 46kD in RAW264.7 cell lysates. Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Short term: -20°C
Long term: -20°C.

Target Details for TACR3

Target: TACR3 (Tachykinin Receptor 3 (TACR3))

Alternative Name: TACR3 / NK3R

Background: Name/Gene ID: TACR3
Subfamily: Tachykinin
Family: GPCR

Synonyms: TACR3, HH11, Nmk-r, NK3R, NKR, Tachykinin receptor 3, Neurokinin B, Neurokinin B receptor, NK-3 receptor, NK-3R, TAC3R, Neurokinin 3 receptor, Neurokinin beta receptor, Neuromedin-K receptor, TAC3RL

Gene ID: 6870

UniProt: P29371

Pathways: Feeding Behaviour