Integrin alpha X (ITGAX) antibody (APC)

Antigen: Integrin alpha X (ITGAX)

Synonyms: CD11C, SLEB6, BR, GPIa, CD49B, VLA-2, VLAA2, VL3A, CD49C, GAPB3, MSK18, VCA-2, VLA3a, GAP-B3, FLJ34631, FLJ34704, IA4, CD49D, MGC90518, FNRA, CD49e, VLA5A, ITGAX, RGD1561123, Cr4, N418, Cd11c, AI449405, CD11c

Clonality: Monoclonal (BU15)

Host: Mouse

Reactivity: Human, Dog (Canine), Monkey

Conjugate: APC

Application: Flow Cytometry (FACS)

Catalog no.: ABIN301988

Additional Information

Alternative name: CD11c

Immunogen: Dendritic cells of synovial fluid

Isotype: IgG1

Clone: BU15

Description: CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit)and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds tocomplement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interactionof CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparincounteracts binding of iC3b.

Specificity: The antibody BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainlyon dendritic cells and tissue macrophages.HLDA III, WS Code M 256HLDA V, WS Code AS S143HLDA VI, WS Code AS Ref.6

Synonyms: CD11C, SLEB6, BR, GPIa, CD49B, VLA-2, VLAA2, VL3A, CD49C, GAPB3, MSK18, VCA-2, VLA3a, GAP-B3, FLJ34631, FLJ34704, IA4, CD49D, MGC90518, FNRA, CD49e, VLA5A, ITGAX, RGD1561123, Cr4, N418, Cd11c, AI449405, CD11c

Application Details

Application Notes: The reagent is designed for Flow Cytometry analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

Storage: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Research Area: Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only

Images

Surface staining of human peripheral blood cells with anti-CD11c (BU15) PerCP (monocyte gate).