CD11c antibody (AA 637-827)

Catalog No. ABIN6939818

Cited in 1 publication. The Mouse Monoclonal anti-CD11c antibody (Clone ITGAX-1242) (ABIN6939818) specifically detects CD11c in IHC and StM. The antibody is reactive with Human samples.

Quick Overview for CD11c antibody (AA 637-827) (ABIN6939818)

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11c antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: ITGAX-1242

Product Details anti-CD11c Antibody

Binding Specificity: AA 637-827

Specificity: Recognizes a protein of 145 kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

Purification: Purified by Protein A/G

Immunogen: Recombinant human ITGAX protein fragment (aa 637-827) (exact sequence is proprietary)

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: THP-1 cells. Tonsil or Lymph Node.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

References for anti-CD11c antibody (ABIN6939818)

Gajawada, Günther, Rolf, Nabhanizadeh, Savai, Choi, Richter: "Transcriptomic profiling of granuloma in patients with cardiac sarcoidosis." in: Theranostics, Vol. 15, Issue 13, pp. 6044-6057, (2025) (PubMed).

Target Details for CD11c

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Alternative Name: ITGAX

Molecular Weight: 145kDa

Gene ID: 3687

UniProt: P20702

Pathways: Complement System, Activated T Cell Proliferation, Integrin Complex