CRP antibody

Antigen: CRP

Clonality: Monoclonal (C7)

Host: Mouse

Reactivity: Human

Application: ELISA

Catalog no.: ABIN302074

Additional Information

Immunogen: Purified human CRP

Format: Purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: C7

Description: The C-reactive protein (CRP) is a cyclic pentameric pentraxin family acute phase proteincompound of five identical noncovalently bound nonglycosylated subunits (each subunit 24kDa, physiologic CRP molecule 117,5 kDa). CRP is produced by the liver and its plasmalevels rise dramatically during inflammatory processes occuring in the body. CRP is aninitiator of classical complement cascade, binds to several nuclear components (chromatin,histones, etc.) and is also believed to play an important role in innate immunity. Patients withelevated basal levels of CRP are at increased risk for hypertension and cardiovasculardisease.

Specificity: The antibody C7 recognizes human CRP, an 117 kDa acute phase protein, it recognizesantigen both in the presence and in the absence (samples containing EDTA) of Ca2+.

Application Details

Application Notes: ELISA: The antibody C7 has been tested as the detection antibody in a sandwich ELISA for analysis of human C-Reactive Protein in combination with the antibody C5 (cat. no. 11-480-C100).

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified from ascites by protein-A affinity chromatography.

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Research Area: Neurology

Restrictions: For Research Use only

Publications

Publications: Sollier, Mandon, Heyries et al.: ""Print-n-Shrink" technology for the rapid production of microfluidic chips and protein microarrays." in: Lab on a chip, Vol. 9, Issue 24, pp. 3489-94, 2009 (PubMed).