XCR1 antibody

Catalog No. ABIN302346

The Rabbit Polyclonal anti-XCR1 antibody (ABIN302346) specifically detects XCR1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for XCR1 antibody (ABIN302346)

Target: XCR1 (Chemokine (C Motif) Receptor 1 (XCR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XCR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-XCR1 Antibody

Specificity: This antibody detects Chemokine (C Motif) XC Receptor 1 (CCXCR1).

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from Human XCR1.

Application Details

Application Notes: Immunohistochemistry on paraffin sections (2.5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for XCR1

Target: XCR1 (Chemokine (C Motif) Receptor 1 (XCR1))

Alternative Name: XCR1 / GPR5

Background: CCXCR1 is a Chemokine Receptor expressed in lymphotactin-responsive leukocyte cells. The viral macrophage inflammatory protein-II, vMIP-II (but not vMIP-I), has been found to be an antagonist of lymphotactin activity at CCXCR1. The CCXCR1 gene is located near the genes for C-C chemokine receptor 9 and SIV/HIV receptor Bonzo on chromosome 3. CCXCR1 is associated with inflammatory and immunological responses by regulating the trafficking of T and B lymphocytes and neutrophils. The up-regulation of CCXCR1 in peripheral T cells is correlated with the inflammatory process observed in Crohns disease.Synonyms: CCXCR1, Chemokine XC receptor 1, G-protein coupled receptor 5, Lymphotactin receptor, XC chemokine receptor 1

Gene ID: 2829

NCBI Accession: NP_001019815

UniProt: P46094