LEF-1 Transactivation Domain antibody
The Mouse Monoclonal anti-LEF-1 Transactivation Domain antibody (Clone 3A12) (ABIN306723) specifically detects LEF-1 Transactivation Domain in WB.
The antibody is reactive with Human samples.
Catalog No. ABIN306723
$368.50
Plus shipping costs $50.00
100 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Quick Overview for LEF-1 Transactivation Domain antibody (ABIN306723)
Target
LEF-1 Transactivation Domain
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Application
Western Blotting (WB)
Clone
3A12
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Purpose
- Mouse anti Human LEF-1 transactivation domain
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Cross-Reactivity
- Human
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Characteristics
- Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. However, it is not present in some splice variants.
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Purification
- Protein A/G Chromatography
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Immunogen
- .
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Isotype
- IgG1
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Application Notes
- Antibody detects amino acids 236-242 of human LEF-1. Epitope is missing in some splice variants. Optimal concentration should be evaluated by serial dilutions.
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Restrictions
- For Research Use only
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Storage
- -20 °C
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Storage Comment
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- LEF-1 Transactivation Domain
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Background
- Anti-Lymphoid Enhancer Factor-1, Transactivation Domain (amino acids 236-242) Monoclonal Antibody
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UniProt
- Q9UJU2
Target
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