ACVR1 antibody (Extracellular Domain)

Catalog No. ABIN306860

The Sheep Polyclonal anti-ACVR1 antibody is suitable to detect ACVR1 in samples from Chicken. It has been validated for WB.

Quick Overview for ACVR1 antibody (Extracellular Domain) (ABIN306860)

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Reactivity: Chicken

Host: Sheep

Clonality: Polyclonal

Conjugate: This ACVR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACVR1 Antibody

Binding Specificity: Extracellular Domain

Purpose: Sheep anti Chicken Alk2

Cross-Reactivity: Chicken

Characteristics: Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor- (TGF- ). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7.

Purification: Ammonium Sulfate Precipitation

Immunogen: Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (5-10 μg/mL), immunoprecipitation (5 μg/mg of protein lysate and immunohistochemistry on paraffin embedded tissue sections (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for ACVR1

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Alternative Name: Alk2

Background: Activin Receptor-Like Kinase 2

UniProt: Q90ZK6