APCS antibody (full length)

Catalog No. ABIN306863

The Rabbit Polyclonal anti-APCS antibody is suitable to detect APCS in samples from Human. It has been validated for WB and IP.

Quick Overview for APCS antibody (full length) (ABIN306863)

Target: APCS (Amyloid P Component, Serum (APCS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APCS antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-APCS Antibody

Binding Specificity: full length

Purpose: Rabbit anti Human SH21A (SH2 DOMAIN-CONTAINING PROTEIN 1A) / (SAP)

Cross-Reactivity: Human

Characteristics: SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.

Purification: Ammonium Sulfate Precipitation

Immunogen: Full-length recombinant SAP protein

Isotype: IgG

Application Details

Application Notes: This antibody can be used for Western blotting (5-10 μg/mL) and immunoprecipiation. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Alternative Name: SAP

Background: SAP, DSHP, SLAM ASSOCIATED PROTEIN

UniProt: O60880