APCS antibody (AA 143-223)

Catalog No. ABIN6939659

Product Details anti-APCS Antibody

Target: APCS (Amyloid P Component, Serum (APCS))

Binding Specificity: AA 143-223

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APCS antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)

Clone: APCS-3240

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: Human endometrial carcinoma tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Alternative Name: APCS (APCS Products)

Synonyms: PTX2 antibody, SAP antibody, Sap antibody, APCS antibody, FP antibody, SAP(FP) antibody, apcs antibody, ptx2 antibody, sap antibody, amyloid P component, serum antibody, serum amyloid P-component antibody, amyloid P component, serum protein L homeolog antibody, APCS antibody, Apcs antibody, apcs.L antibody

Background: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

Molecular Weight: 200kDa (oligomeric), 26kDa (non-covalently bound subunit), 30kDa (glycosylated SAP subunit)

Gene ID: 325

UniProt: P02743