CACNA1A antibody

Catalog No. ABIN306878

The Rabbit Polyclonal anti-CACNA1A antibody is suitable to detect CACNA1A in samples from Rat. It has been validated for WB.

Quick Overview for CACNA1A antibody (ABIN306878)

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CACNA1A Antibody

Purpose: Rabbit anti Rat Calcium Channel

Characteristics: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the rat 1A calcium channel conjugated to KLH

Isotype: IgG

Application Details

Application Notes: This antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for CACNA1A

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Alternative Name: a1ACalcium Channel

Background: Voltage-gated calcium channel subunit alpha Cav2.1,Calcium channel, L type, alpha-1 polypeptide, isoform 4, Brain calcium channel I

UniProt: P54282

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process