CACNA1C antibody

Catalog No. ABIN306886

This Rabbit Polyclonal antibody specifically detects CACNA1C in WB. It exhibits reactivity toward Human.

Quick Overview for CACNA1C antibody (ABIN306886)

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CACNA1C Antibody

Purpose: Rabbit anti Human Calcium Channel

Cross-Reactivity: Human

Characteristics: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the rat beta3 calcium channel conjugated to KLH

Isotype: IgG

Application Details

Application Notes: This antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for CACNA1C

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Alternative Name: Calcium Channel

Background: Voltage-Dependent L-Type Calcium Channel, beta3 subunit

UniProt: P54284

Pathways: Hormone Transport, Carbohydrate Homeostasis