Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) antibody

Catalog No. ABIN306920

The Rabbit Polyclonal anti-Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) antibody is suitable to detect Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) in samples from Human. It has been validated for WB.

Quick Overview for Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) antibody (ABIN306920)

Target: Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details

Purpose: Rabbit anti Human Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) NT

Cross-Reactivity: Human

Characteristics: EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine 1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.

Purification: Ammonium Sulfate Precipitation

Isotype: IgG

Application Details

Application Notes: Detects EDG6 (S1P4) receptors at concentration of 5-10 μg/mL by Western blot using a human EDG6 (S1P4) receptor transfected cell line. Detects an approximately 45 kDa band in Cos cells transfected with full length human EDG6 (S1P4) . Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.

Restrictions: For Research Use only

Handling

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details

Target: Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)

Background: Endothelial cell differentiation gene 6, N terminal, Sphingosine 1-Phosphate Receptor-4 (S1P4)

UniProt: O95977