LASS1 antibody

Catalog No. ABIN307130

The Rabbit Polyclonal anti-LASS1 antibody is suitable to detect LASS1 in samples from Human. It has been validated for WB.

Quick Overview for LASS1 antibody (ABIN307130)

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LASS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LASS1 Antibody

Purpose: Rabbit anti Human Lass1 (Cross reacts with GDF1)

Cross-Reactivity: Human

Characteristics: LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane, LAss1 is a multi-pass membrane protein.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the human Lass1 protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL starting dilution). Other uses not yet tested. Only reacts with human Lass1 protein. Also cross reacts with human GDF1. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for LASS1

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Alternative Name: Lass1 (Cross reacts with GDF1)

Background: LAG1 longevity assurance homolog 1, UOG-1 protein, LAG1, LASS1, LAG1 longevity assurance homolog 1 (LASS 1)

UniProt: P27544