Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13) antibody

Catalog No. ABIN307154

The Rabbit Polyclonal anti-Purinergic Receptor P2Y, G-Protein Coupled, 13 antibody is suitable to detect Purinergic Receptor P2Y, G-Protein Coupled, 13 in samples from Human. It has been validated for WB.

Quick Overview for Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13) antibody (ABIN307154)

Target: Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Purpose: Rabbit anti Human G-Protein Coupled Receptor 94

Cross-Reactivity: Human

Characteristics: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined. Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from human GPCR94.

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details

Target: Purinergic Receptor P2Y, G-Protein Coupled, 13 (P2RY13)

Alternative Name: G-Protein Coupled Receptor 94

Background: P2Y Purinoceptor 13, P2Y13, G-protein coupled receptor 86, GPCR94, GPCR86

UniProt: Q9BPV8

Pathways: cAMP Metabolic Process