SMO antibody

Catalog No. ABIN307155

The Rabbit Polyclonal anti-SMO antibody (ABIN307155) specifically detects SMO in WB. The antibody is reactive with Human samples.

Quick Overview for SMO antibody (ABIN307155)

Target: SMO (Smoothened Homolog (Drosophila) (SMO))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMO antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMO Antibody

Purpose: Rabbit anti Human SMO (Smoothened Homolog)

Cross-Reactivity: Human

Characteristics: SMO is a G protein-coupled receptor (GPCR) that putatively associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. The binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). In basal cell carcinoma there are two somatic mutations SMO, D473-> H473 and R562 ->Q562.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the human SMO protein

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for SMO

Target: SMO (Smoothened Homolog (Drosophila) (SMO))

Alternative Name: SMO (Smoothened Homolog)

Background: Smoothened homolog [Precursor], SMO, Gx protein, SMO, SMOH

UniProt: Q99835

Pathways: Hedgehog Signaling