FE65 antibody (Thr668)

Catalog No. ABIN308659

This Rabbit Polyclonal antibody specifically detects FE65 in WB. It exhibits reactivity toward Mouse, Human and Rat.

Quick Overview for FE65 antibody (Thr668) (ABIN308659)

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FE65 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FE65 Antibody

Binding Specificity: Thr668

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: affinity purified

Immunogen: Peptide corresponding to AA surrounding Thr668 of human APP695

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Alternative Name: anti-Fe65

Background: Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease (AD). FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.

Pathways: Positive Regulation of Response to DNA Damage Stimulus