REXO4 antibody (Middle Region)

Catalog No. ABIN309679

This Rabbit Polyclonal antibody specifically detects REXO4 in WB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for REXO4 antibody (Middle Region) (ABIN309679)

Target: REXO4 (REX4, RNA Exonuclease 4 Homolog (REXO4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This REXO4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-REXO4 Antibody

Binding Specificity: Middle Region

Sequence: PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL TRALALDCEM

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against REXO4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human REXO4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 422 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-REXO4 antibody (ABIN309679)

Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, (2005) (PubMed).

Target Details for REXO4

Target: REXO4 (REX4, RNA Exonuclease 4 Homolog (REXO4))

Alternative Name: REXO4

Background: The regulation of the quinone reductase (QR) gene as well as other genes involved in detoxification is known to be mediated by an electrophile response element (EpRE). QR gene regulation by the antiestrogen-occupied estrogen receptor (ER) is mediated by the EpRE-containing region of the human QR gene, and the ER is one of the complex of proteins that binds to the EpRE. REXO4 directly binds to the EpRE and interacts with the ER. The activation of QR gene activity by REXO4 is enhanced in the presence of ER beta.
Alias Symbols: XPMC2, XPMC2H, REX4
Protein Interaction Partner: UBC, SIRT7, ESR2, ESR1,
Protein Size: 422

Molecular Weight: 47 kDa

Gene ID: 57109

NCBI Accession: NM_020385, NP_065118

UniProt: Q9GZR2