REX4, RNA Exonuclease 4 Homolog (S. Cerevisiae) (REXO4) (Middle Region) antibody

Details for Product No. ABIN309679
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Antigen
Synonyms REXO4, im:7156740, xpmc2, REX4, XPMC2, XPMC2H, Gm111, Xpmc2h
Epitope
Middle Region
(2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(12), (4), (4), (1), (1)
Host
Rabbit
(11), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(11), (4), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN309679
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human REXO4
Sequence PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL TRALALDCEM
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against REXO4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name REXO4
Background The regulation of the quinone reductase (QR) gene as well as other genes involved in detoxification is known to be mediated by an electrophile response element (EpRE). QR gene regulation by the antiestrogen-occupied estrogen receptor (ER) is mediated by the EpRE-containing region of the human QR gene, and the ER is one of the complex of proteins that binds to the EpRE. REXO4 directly binds to the EpRE and interacts with the ER. The activation of QR gene activity by REXO4 is enhanced in the presence of ER beta.
Molecular Weight 47 kDa
Gene ID 57109
NCBI Accession NM_020385, NP_065118
UniProt Q9GZR2
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 422 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Product cited in: Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

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