Colony Stimulating Factor 1 (Macrophage) (CSF1) (N-Term) antibody

Details for Product No. ABIN310590
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Antigen
Synonyms CSF1, csf1-1, zgc:172186, CSF-1, MCSF, C87615, Csfm, op
Epitope
N-Term
(4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Human
(98), (34), (14), (13), (13), (12), (1), (1), (1)
Host
Rabbit
(81), (26), (9), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(15), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(98), (78), (27), (11), (10), (8), (7), (6), (3), (3), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310590
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human CSF1
Sequence PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME
Predicted Reactivity Human : 100 %, Rabbit : 90 %, Dog : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against CSF1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CSF1
Background CSF1 is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. CSF1 may be involved in development of the placenta. The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Four transcript variants encoding three different isoforms have been found for this gene.
Molecular Weight 45 kDa
Gene ID 1435
NCBI Accession NP_757349, NM_172210
UniProt Q5VVF3
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 438 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Colony Stimulating Factor 1 (Macrophage) (CSF1) (N-Term) antibody WB Suggested Anti-CSF1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Background publications West, Rubin, Miller et al.: "A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 3, pp. 690-5, 2006 (PubMed).

Validation Images
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