TGFBR2 antibody (N-Term)

Catalog No. ABIN310627

This Rabbit Polyclonal antibody specifically detects TGFBR2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Pig, Sheep and Goat.

Quick Overview for TGFBR2 antibody (N-Term) (ABIN310627)

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Pig, Sheep, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TGFBR2 Antibody

Binding Specificity: N-Term

Sequence: MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SDVEMEAQKD EIICPSCNRT

Predicted Reactivity: Cow: 93%, Goat: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 100%, Rat: 93%, Sheep: 91%

Characteristics: This is a rabbit polyclonal antibody against TGFBR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TGFBR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 567 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TGFBR2

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Alternative Name: TGFBR2

Background: TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII
Protein Interaction Partner: TRAF4, NRP1, NRP2, TGFB1, TERT, PEG10, ENG, GOPC, IQGAP1, UBC, RCVRN, PDGFRA, APP, TGFBR1, MAP3K7, PAK1, OCLN, SMAD7, CDC42, Hsp90aa1, KCNK18, FBXO34, PPP1R16B, OXSR1, ARHGEF6, TRAF6, TSC22D1, SMURF1, OSR1, TCTEX1D4, SNX6, TSSK1B, TGFBRAP1, TRAP1, STRAP,
Protein Size: 567

Molecular Weight: 62 kDa

Gene ID: 7048

NCBI Accession: NM_003242, NP_003233

UniProt: P37173