NR1I3 antibody (N-Term)

Catalog No. ABIN310698

The Rabbit Polyclonal anti-NR1I3 antibody (ABIN310698) specifically detects NR1I3 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig, Cow and Pig samples.

Quick Overview for NR1I3 antibody (N-Term) (ABIN310698)

Target: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR1I3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NR1I3 Antibody

Binding Specificity: N-Term

Purpose: NR1I3 Antibody - N-terminal region

Sequence: MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA

Predicted Reactivity: Cow: 90%, Dog: 92%, Guinea Pig: 79%, Human: 100%, Mouse: 92%, Pig: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against NR1I3. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR1I3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45623-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NR1I3

Target: NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))

Alternative Name: NR1I3

Background:

Background Information: NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses.

Gene Name: Nuclear receptor subfamily 1, group I, member 3

Alternative Symbols: CAR, CAR1, MB67

Protein Name: Nuclear receptor subfamily 1 group I member 3

Molecular Weight: 39kDa

Gene ID: 9970

NCBI Accession: NP_005113

UniProt: Q5VTW5

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway