SIK1 antibody (N-Term)

Catalog No. ABIN310741

This Rabbit Polyclonal antibody specifically detects SIK1 in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Horse, Dog, Guinea Pig, Cow, Pig and Rabbit.

Quick Overview for SIK1 antibody (N-Term) (ABIN310741)

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Reactivity: Human, Rat, Mouse, Horse, Dog, Guinea Pig, Cow, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SIK1 Antibody

Binding Specificity: N-Term

Purpose: SNF1LK Antibody - N-terminal region

Sequence: MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 90%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SNF1LK. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNF1LK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111111

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Alternative Name: SNF1LK

Background:

Background Information: SNF1LK play a transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. It also plays a potential role in G2/M cell cycle regulation. It inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.

Gene Name: Salt-inducible kinase 1

Alternative Symbols: MSK, SIK, DEE30, SIK-1, SIK1B, SNF1LK

Protein Name: Serine/threonine-protein kinase SIK1

Molecular Weight: 85 kDa

Gene ID: 150094

NCBI Accession: NP_775490

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process