Centromere Protein A (CENPA) antibody

Antigen: Centromere Protein A (CENPA)

Synonyms: CENP-A, Cenp-A, BcDNA:RE21270, cenH3, CenH3, CenH3[Cid], CENP-A/Cid, CENP-A/CID, cenpA, CenpA, CENPA, CenpA/CID, CG13329, Cid, CID, CID/CENP-A, Cid[Mel], DmelCG13329, cenpx, cenp-a, sim2, cnp1, Cenp-a, RGD1563607, cenpa, MGC85062

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Catalog no.: ABIN310757

Additional Information

Alternative name: CENP-A

Gene ID: CENPA

Immunogen: The immunogen for anti-CENPA antibody: synthetic peptide directed towards the N terminal of human CENPA

Sequence: MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQH SRRRQGWLKE

Cross-Reactivity: Human

Format: Lyophilized

Reconstitution: Add 100 µl of distilled water. Final anti-CENPA antibody concentration is 1 mg/ml.

Description: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA is a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.

Characteristics: Antigen Size: 140 amino acids

Molecular Weight: 16kDa

Synonyms: CENP-A, Cenp-A, BcDNA:RE21270, cenH3, CenH3, CenH3[Cid], CENP-A/Cid, CENP-A/CID, cenpA, CenpA, CENPA, CenpA/CID, CG13329, Cid, CID, CID/CENP-A, Cid[Mel], DmelCG13329, cenpx, cenp-a, sim2, cnp1, Cenp-a, RGD1563607, cenpa, MGC85062

Application Details

Purification: Protein A purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Restrictions: For Research Use only

Images

anti-Centromere Protein A (CENPA) antibody

anti-Centromere Protein A (CENPA) antibody (Image 2)

Publications

Black, Foltz, Chakravarthy et al.: "Structural determinants for generating centromeric chromatin." in: Nature, Vol. 430, Issue 6999, pp. 578-82, 2004 (PubMed).