PDSS1 antibody (Middle Region)

Catalog No. ABIN310788

The Rabbit Polyclonal anti-PDSS1 antibody (ABIN310788) specifically detects PDSS1 in WB. The antibody is reactive with Human, Mouse, Cow, Dog, Guinea Pig, Rabbit, Rat and Horse samples.

Quick Overview for PDSS1 antibody (Middle Region) (ABIN310788)

Target: PDSS1 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 (PDSS1))

Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Rabbit, Rat, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDSS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDSS1 Antibody

Binding Specificity: Middle Region

Purpose: PDSS1 Antibody - middle region

Sequence: VIDDASSRRG KHTVNKIWGE KKAVLAGDLI LSAASIALAR IGNTTVISIL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PDSS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PDSS1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8108880

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDSS1

Target: PDSS1 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 (PDSS1))

Alternative Name: PDSS1

Background:

Targeted Subunit: 1

Background Information: PDSS1 is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. PDSS1 catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in PDSS1 gene are a cause of coenzyme Q10 deficiency.The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency.

Gene Name: Prenyl (decaprenyl) diphosphate synthase, subunit 1

Alternative Symbols: DPS, SPS, TPT, COQ1, TPRT, COQ1A, TPT 1, hDPS1, COQ10D2

Protein Name: Decaprenyl-diphosphate synthase subunit 1

Molecular Weight: 46kDa

Gene ID: 23590

NCBI Accession: NP_055132

UniProt: Q5T2R2